Jumonji, AT Rich Interactive Domain 2 (JARID2) (Middle Region) Peptide
JARID2
Reactivité: Souris
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits JARID2
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
- Protein Region
- Middle Region
- Origine
- Souris
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Jarid2 Antibody(ARP37307_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
- Synonymes
- JMJ Peptide, Jmj Peptide, jumonji Peptide, JARID2 Peptide, jarid2 Peptide, jmj Peptide, si:dkey-211c3.1 Peptide, Jumonji Peptide, jarid2-a Peptide, jarid2-b Peptide, jarid2.S Peptide, jarid2b Peptide, jumonji and AT-rich interaction domain containing 2 Peptide, jumonji, AT rich interactive domain 2 Peptide, jumonji, AT rich interactive domain 2a Peptide, jumonji, AT rich interactive domain 2b Peptide, jumonji and AT-rich interaction domain containing 2 L homeolog Peptide, JARID2 Peptide, Jarid2 Peptide, jarid2a Peptide, jarid2 Peptide, jarid2b Peptide, jarid2.L Peptide
- Sujet
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Jarid2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Jarid2 acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.Jarid2 binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.Jarid2 does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.Jarid2 also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5.Jarid2 participates in the negative regulation of cell proliferation signaling.
Alias Symbols: AI317256, AU045941, C79929, C79931, Jmj, jumonji
Protein Interaction Partner: Aebp2,BC018507,Bclaf1,Eed,Ell,Ewsr1,Ezh1,Ezh2,Morc3,Mtf2,Rbbp4,Setx,Stk38,Stk38l,Suz12,Thrap3,Trim35
Protein Size: 1234 - Poids moléculaire
- 137 kDa
- ID gène
- 16468
- NCBI Accession
- NM_021878, NP_068678
- UniProt
- Q62315
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