Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Peptide
MAP3K8
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits MAP3K8
- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MAP3K8 antibody (Catalog #: ARP30649_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
- Synonymes
- MAP3K8 Peptide, COT Peptide, EST Peptide, ESTF Peptide, MEKK8 Peptide, TPL2 Peptide, Tpl-2 Peptide, c-COT Peptide, Cot Peptide, Cot/Tpl2 Peptide, Est Peptide, Estf Peptide, Tpl2 Peptide, D17TPL2 Peptide, mitogen-activated protein kinase kinase kinase 8 Peptide, MAP3K8 Peptide, map3k8 Peptide, Map3k8 Peptide
- Sujet
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MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
Alias Symbols: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
Protein Interaction Partner: AKT1,BMPR2,CD40,CHUK,MAP2K4,MAP3K14,NFKB1,NFKB2,REL,RELA,RIPK1,TNIP2,TRAF2,TRAF6,AKT1,CHUK,KSR2,MAP2K1,MAP2K4,MAP3K14,NFKB1,NFKB2,REL,RELA,TNIP2,TRAF2
Protein Size: 467 - Poids moléculaire
- 53 kDa
- ID gène
- 1326
- NCBI Accession
- NM_005204, NP_005195
- UniProt
- P41279
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