MAP3K8 Produits
(Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
Catégories
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].
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Catégories MAP3K8 en vedette
MAP3K8 Anticorps
High quality antibodies with extensive validation data.
MAP3K8 Kits ELISA
Reliable ELISA kits for a wide range of species.
MAP3K8 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MAP3K8 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (5)
N° du produit
ABIN701275
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (4)
N° du produit
ABIN7160057
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p), IF, ICC
Validations
- (4)
N° du produit
ABIN2855464
Quantité
100 μL
Fiche technique
Fiche technique
MAP3K8 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380113
Quantité
2 x 96 tests
Fiche technique
Fiche technique
MAP3K8 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (2)
N° du produit
ABIN5569959
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
N° du produit
ABIN5569958
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310237
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MAP3K8
: "TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth." dans: PLoS ONE, Vol. 6, Issue 1, pp. e16205, (2011) (PubMed).: "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis." dans: Diabetes, Vol. 59, Issue 1, pp. 61-70, (2009) (PubMed).
: "Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7984-93, (2009) (PubMed).
: "Tpl2 is a key mediator of arsenite-induced signal transduction." dans: Cancer research, Vol. 69, Issue 20, pp. 8043-9, (2009) (PubMed).
: "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction." dans: Immunity, Vol. 29, Issue 1, pp. 12-20, (2008) (PubMed).
: "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation." dans: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31379-86, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à MAP3K8
mitogen-activated protein kinase kinase kinase 8 (MAP3K8), mitogen-activated protein kinase kinase kinase 8 (map3k8), mitogen-activated protein kinase kinase kinase 8 (Map3k8), c-COT, COT, Cot, Cot/Tpl2, D17TPL2, EST, Est, ESTF, Estf, MAP3K8, MEKK8, Tpl-2, TPL2, Tpl2Protein level used designations for MAP3K8
- mitogen-activated protein kinase kinase kinase 8
- Ewing sarcoma transformant
- cot (cancer Osaka thyroid) oncogene
- proto-oncogene c-Cot
- proto-oncogene serine/threoine protein kinase
- tumor progression locus 2
- COT proto-oncogene serine/threonine-protein kinase
- cancer Osaka thyroid oncogene
- cancer Osaka thyroid, oncogene
- mitogen activated protein kinase kinase kinase 8
- serine/threonine-protein kinase cot
- serine/threonine kinase (Tpl-2)
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