This is a synthetic peptide designed for use in combination with anti-MED7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: CRSP33, CRSP9, MGC12284, ARC34
Protein Interaction Partner: HGS,MED8,MED9,BARHL1,CDK8,CTDP1,ESR1,ESR2,FXR2,HGS,HNF4A,IKBKG,LZTR1,MED1,MED10,MED14,MED15,MED19,MED22,MED25,MED26,MED28,MED29,MED31,MED9,PARP1,PCBD2,PML,RBFOX2,RELA,RHOXF2,SREBF1,TRIM15,TRIM29,UBAC1,VDR,ZSCAN1