Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) Peptide
NFKBIA
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
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- Antigène Tous les produits NFKBIA
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-NFKBIA antibody (Catalog #: P100940_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- Synonymes
- IKBA Peptide, MAD-3 Peptide, NFKBI Peptide, AI462015 Peptide, Nfkbi Peptide, RL/IF-1 Peptide, ECI-6/IKBA Peptide, NFKBIA Peptide, ikbaB Peptide, wu:fb81f08 Peptide, zgc:56666 Peptide, zgc:77616 Peptide, ikbaA Peptide, wu:fj16a07 Peptide, zgc:85769 Peptide, NFKB inhibitor alpha Peptide, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Peptide, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b Peptide, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a Peptide, NFKBIA Peptide, Nfkbia Peptide, nfkbiab Peptide, nfkbiaa Peptide
- Sujet
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NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
Alias Symbols: IKBA, MAD-3, NFKBI
Protein Interaction Partner: ARRB1,ARRB2,BTRC,CHUK,CHUK,COMMD1,DYNLL1,ERC1,HDAC1,HDAC3,IKBKB,IKBKB,IKBKB,LCK,NFKB1,RELA,RELA,ARRB1,ARRB2,BTRC,CAPN1,CAPN2,CDC34,CHUK,COMMD1,COPS8,CSNK2A1,CUL1,DYNLL1,EIF2AK2,FBXW11,G3BP2,HDAC1,HDAC3,HNRNPA1,HOXA9,HOXB7,HSPB1,IKBKAP,IKBKB,IKBKE,IKBKG,JAK2,LCK,MAP3K2,MAP3K3,MCM5,MCM7,MED19,NCOR2,NFKB1,NFKB2,NFKBIB,NKIRAS1,NKIRAS2,PIK3R1,POM121,PRKCI,PTPN1,PTPN13,REL,RELA,RPS6KA1,SKP1,SLC25A4,SLC25A5,SRC,SUMO1,SUMO4,TBK1,TNFSF11,TP53,TUBA1B,UBE2D2,UBE2D3,UBE2E3,VCP,AURKA,BARD1,BTRC,CAPN1,CHUK,COMMD1,DYNLL1,FBXW11,G3BP2,HNRNPA1,HOXB7,IKBKAP,IKBKB,LYL1,MAP3K14,MED19,NCOR2,NFKB1,PIK3R1,PIR,POM121,PTPN13,REL,RELA,RPS6KA1,SUMO4,TP53,UBC,UBE2D1,UBE2E3,VCP
Protein Size: 317 - Poids moléculaire
- 36 kDa
- ID gène
- 4792
- NCBI Accession
- NM_020529, NP_065390
- UniProt
- P25963
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