This is a synthetic peptide designed for use in combination with anti-PCAF antibody (Catalog #: ARP32466_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Alias Symbols: P, CAF, PCAF, P/CAF
Protein Interaction Partner: ALB,CTBP1,H3F3A,HIST4H4,NCOA3,PGR,RB1,TACC2,bel-1,tat,ACTN1,ACTN2,AR,BRCA2,CCND1,CDC25B,CIITA,CREBBP,CTBP1,CUX1,DACH2,EP300,ETV1,GATAD2A,GATAD2B,H3F3B,HIPK2,HMGN2,HNF1A,ING1,IRF1,IRF2,IRF7,JDP2,KAT2B,KLF13,MDM2,MECOM,MYOD1,NCOA1,NCOA3,NCOA4,NFE4,NOTCH1,NOTCH3,NPAS2,NR4A1,NRIP1,ONECUT1,RARA,RBPJ,RELA,SATB1,SIRT2,SMAD1,SMAD2,SMAD3,SRCAP,TACC2,TAL1,TCF3,TP53,TP73,TTF1,TWIST1,ARNTL,BRCA2,CCND1,CDC25B,CDK8,CLOCK,CREBBP,CTBP1,CTNNB1,CUX1,EP300,HIST3H3,HIST4H4,HNF1A,ING1,IRF1,IRF2,KLF13,MDM2,MECOM,MED21,MYC,NCOA1,NCOA4,NPAS2,NR4A1,Notch1,ONECUT1,POLR2A,RARA,RBPJ,SMARCB1,SUPT3H,TAF10,TAF5L,TAF9,TCF3,TP53,TRRAP,TTF1,TWIST1,YY1