POU Class 1 Homeobox 1 (POU1F1) (Middle Region) Peptide
POU1F1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits POU1F1
- POU1F1 (POU Class 1 Homeobox 1 (POU1F1))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-POU1F1 antibody (Catalog #: ARP32318_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- POU1F1 (POU Class 1 Homeobox 1 (POU1F1))
- Synonymes
- CPHD1 Peptide, GHF-1 Peptide, PIT1 Peptide, POU1F1a Peptide, Pit-1 Peptide, Hmp1 Peptide, Pit1 Peptide, Pit1-rs1 Peptide, dw Peptide, dwarf Peptide, GHF1 Peptide, GHF1A Peptide, PIT1Z Peptide, PIT-1 Peptide, Pit-1* Peptide, pit1 Peptide, pit-1 Peptide, POU class 1 homeobox 1 Peptide, POU domain, class 1, transcription factor 1 Peptide, POU1F1 Peptide, Pou1f1 Peptide, pou1f1 Peptide
- Sujet
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PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP. This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: GHF-1, PIT1, Pit-1, Pit-1 beta, CPHD1, POU1F1a
Protein Interaction Partner: CREBBP,ETS1,GATA2,JUN,NR1I2,NR1I3,NR3C1,PITX1,GATA2,JUN,NR1I2,NR1I3,NR3C1,PITX1,PPARA,PPARG,VDR
Protein Size: 291 - Poids moléculaire
- 33 kDa
- ID gène
- 5449
- NCBI Accession
- NM_000306, NP_000297
- UniProt
- P28069
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