Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) Peptide
PRMT2
Reactivité: Humain
Hôte: Synthetic
BP, WB, ChIP
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- Antigène Tous les produits PRMT2
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-PRMT2 antibody (Catalog #: ARP40195_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Synonymes
- PRMT2 Peptide, DKFZp459N1919 Peptide, HRMT1L1 Peptide, Hrmt1l1 Peptide, AI504737 Peptide, protein arginine methyltransferase 2 Peptide, protein arginine methyltransferase 2 L homeolog Peptide, protein arginine N-methyltransferase 2 Peptide, PRMT2 Peptide, Prmt2 Peptide, prmt2.L Peptide
- Sujet
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The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Alias Symbols: HRMT1L1, MGC111373
Protein Interaction Partner: ESR1,ESR2,NCOA1,NCOA6,PGR,PPARG,PRMT2,RARA,RXRA,THRB,BAT2,CPSF7,DMRTB1,ESR1,ESR2,HNRNPUL1,NCOA1,NCOA6,PGR,PRMT2,RB1,RXRA,THRB,BAT2,CPSF7,DMRTB1,ESR1,HNRNPUL1
Protein Size: 433 - Poids moléculaire
- 49 kDa
- ID gène
- 3275
- NCBI Accession
- NM_001535, NP_001526
- UniProt
- P55345
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