Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (N-Term) Peptide
PSMD10
Reactivité: Souris
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits PSMD10
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Protein Region
- N-Term
- Origine
- Souris
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- KERILADKSL ATRTDQDSRT ALHWACSAGH TEIVEFLLQL GVPVNDKDDA
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Psmd10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Synonymes
- gankyrin Peptide, zgc:109707 Peptide, dJ889N15.2 Peptide, p28 Peptide, p28(GANK) Peptide, AW554874 Peptide, p28Gank Peptide, proteasome 26S subunit, non-ATPase 10 Peptide, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Peptide, psmd10 Peptide, PSMD10 Peptide, Psmd10 Peptide
- Sujet
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Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
Alias Symbols: AW554874
Protein Size: 231 - Poids moléculaire
- 25 kDa
- ID gène
- 53380
- NCBI Accession
- NM_016883, NP_058579
- UniProt
- Q9Z2X2
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