Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (N-Term) Peptide
STAT3
Reactivité: Humain
Hôte: Synthetic
BP, WB, IF, IHC
N° du produit ABIN984529
150,78 €
Plus frais de livraison 40,00 € et TVA
100 μg
Destination:
France
Envoi sous 15 à 22 jours ouvrables
Aperçu rapide pour Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (N-Term) Peptide (ABIN984529)
Antigène
STAT3
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-STAT3 antibody (Catalog #: ARP38253_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) peptide
STAT3 Reactivité: Humain, Souris, Rat, Chien Hôte: Synthetic BP, Imm
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
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Sujet
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STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. It mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: APRF, FLJ20882, MGC16063, HIES
Protein Interaction Partner: NMI,BHLHE40,CREBBP,EGFR,EP300,HDAC1,HDAC2,HDAC3,NMI,PRKCB,PRKCD,STAT3,BHLHE40,AR,BHLHE40,BMX,BRCA1,CCND1,CCR1,CCR5,CDKN1A,CREBBP,CSF2RB,CSF3R,CXCR4,DAXX,EGFR,EIF2AK2,ELP2,EP300,EPHA3,FER,FES,FGFR3,FGFR4,FOXM1,GATA1,GATA2,GHR,GNB2L1,GTF2I,HCK,HDAC1,HDAC2,HDAC3,HES1,HES5,HIF1A,HNF1A,HSP90AA1,HSP90AB1,IFNAR1,IFNAR2,IGF1R,IL1RAP,IL23R,IL2RA,IL2RB,IL6R,IL6ST,IL7R,IRAK1,JAK1,JAK2,JAK3,JUN,KAT5,KHDRBS1,KPNA1,KPNA6,LCK,LEPR,MAP3K7,MAPK1,MAPK3,MAPK8,MET,MTOR,MYOD1,NCOA1,NDUFA13,NFKB1,NLK,NMI,NR3C1,PDGFRA,PDGFRB,PDIA3,PIAS3,PML,PRKCD,PTK2B,PTMA,PTPN11,PTPN2,RAC1,RELA,RET,RPA2,RPS6KA5,SRC,STAP2,STAT1,STAT3,STAT4,STAT5A,STAT5B,STMN1,SUMO4,SYK,TSHR,TSLP,ZNF148,ZNF467,A2M,ALK,AR,BMX,CCND1,CCND1,CCR5,CDKN1A,CREBBP,CTR9,EGFR,EIF2AK2,ELP2,EP300,EPHA5,ERBB2,ESR1,FES,FOS,GHR,GTF2I,HIF1A,HNF1A,HSP90AA1,IFNAR1,IL1RAP,IL2RB,IL6R,IL6ST,IL6ST,JAK1,JAK2,JUN,KAT5,KHDRBS1,LEP,MET,MTOR,MYOD1,NCOA1,NDUFA13,NDUFA13,NFKB1,NMI,NR3C1,PDIA3,PIAS3,PML,PTK2,PTPN11,PTPN2,RAC1,RELA,RET,RPA2,SMAD1,SRC,STAT1,TRIP10,TSHR
Protein Size: 769 -
Poids moléculaire
- 88 kDa
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ID gène
- 6774
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NCBI Accession
- NM_003150, NP_003141
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UniProt
- B5BTZ6
Antigène
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