TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) Peptide
TIAL1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TIAL1
- TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TIAL1 antibody (Catalog #: AVARP02048_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))
- Synonymes
- TCBP Peptide, TIAR Peptide, 5330433G13Rik Peptide, AL033329 Peptide, mTIAR Peptide, zgc:66130 Peptide, tcbp Peptide, tiar Peptide, TIA1 cytotoxic granule associated RNA binding protein like 1 Peptide, Tia1 cytotoxic granule-associated RNA binding protein-like 1 Peptide, TIA1 cytotoxic granule-associated RNA binding protein-like 1 Peptide, TIAL1 Peptide, Tial1 Peptide, tial1 Peptide
- Sujet
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The protein encoded by TIAL1 is a member of a family of RNA-binding proteins and possesses nucleolytic activity against cytotoxic lymphocyte target cells. The gene product is a cytotoxic granule-associated protein and has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. It has been suggested that members of this protein family may be involved in the induction of apoptosis. One isoform contains a lysosome-targeting motif in its C-terminal auxiliary domain, however, alternative splicing results in a T-cluster DNA-binding isoform, differing at the C-terminus where a hydrophobic sequence replaces the lysosome-targeting motif.
Alias Symbols: TCBP, TIAR
Protein Interaction Partner: SMN2,SMN2
Protein Size: 375 - Poids moléculaire
- 42 kDa
- ID gène
- 7073
- NCBI Accession
- NM_003252, NP_003243
- UniProt
- Q01085
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