This is a synthetic peptide designed for use in combination with anti-TRPC3 antibody (Catalog #: ARP58715_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
TRPC3 is thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC3 is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. TRPC3 may also be activated by internal calcium store depletion.
Alias Symbols: TRP3
Protein Interaction Partner: MX1,NAPA,VAMP2,CALM1,FKBP1A,GNA11,ITPR1,ITPR3,MX1,NAPA,ORAI1,PLCB1,PLCB2,PLCB3,PLCG1,PLCG1,PRKCA,PRKG1,SLC8A1,STX3,TRPC1,TRPC6,VAMP2,ITPR1,ITPR3,TRPC1,TRPC3,TRPC4,TRPC5,TRPC6,TRPC7