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anti-Human HTRA2 Anticorps:
anti-Mouse (Murine) HTRA2 Anticorps:
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Human Polyclonal HTRA2 Primary Antibody pour IF, WB - ABIN223216
Griparic, Kanazawa, van der Bliek: Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage. dans The Journal of cell biology 2007
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Human Monoclonal HTRA2 Primary Antibody pour IHC (p), IHC - ABIN252514
Laforge, Bidère, Carmona, Devocelle, Charpentier, Senik: Apoptotic death concurrent with CD3 stimulation in primary human CD8+ T lymphocytes: a role for endogenous granzyme B. dans Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Monoclonal HTRA2 Primary Antibody pour IHC (p), WB - ABIN532000
Lee, Lee, Kim, Kim, Park, Kim, Lee, Yoo: Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. dans APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003
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Mitochondrial serine protease HtrA2 (Montrer F2 Anticorps)/Omi is an important mediator of germ cell death.
Data show the presence of apoptosis at the cellular level in both ade2 (Montrer PAICS Anticorps) and Prat (Montrer PPAT Anticorps) mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
Drosophila Omi (dOmi), a fly homologue of the serine protease Omi/HtrA2, alleviates th/DIAP1 (Montrer DIAPH1 Anticorps) inhibition of all caspases by proteolytically degrading th/DIAP1 (Montrer DIAPH1 Anticorps) and induces apoptosis both in cultured cells and in the developing fly eye.
The binding of DIAP1 (Montrer DIAPH1 Anticorps) to dOmi resulted in DIAP1 (Montrer DIAPH1 Anticorps)-mediated polyubiquitination of dOmi, suggesting that DIAP1 (Montrer DIAPH1 Anticorps) could target dOmi for proteasomal degradation.
found that Rhomboid-7, a mitochondrial protease not previously implicated in PD, acts as an upstream component of this pathway, and showed that it is required to cleave the precursor forms of both Pink1 (Montrer PINK1 Anticorps) and Omi
HtrA2 was shown to be phosphorylated in a PINK1 (Montrer PINK1 Anticorps)-dependent manner, suggesting it might act in the PINK1 (Montrer PINK1 Anticorps) pathway.
The association between the change in HtrA2 and proteins associated with LATS1 (Montrer LATS1 Anticorps) in ovarian serous cancer cell lines after repeated treatment with cisplatin was evaluated in vitro. In immunohistochemical analysis, repeated cisplatin treatment induced downregulation of HtrA2 protein expression, before and after cisplatin-based chemotherapy in SAC (Montrer ADCY10 Anticorps).
STEMI patients with elevated circulating HtrA2 levels were identified as having ischemia-reperfusion injury.
The important functions for HTRA2 in programmed cell death.
A pathogenic role of serine protease HtrA2 (Montrer F2 Anticorps) in Parkinson's and Alzheimer's diseases has been described. (Review)
The first report of recessive deleterious mutations in HTRA2 in human. Absence of HTRA2/Omi is associated with severe neurodegenerative disorder of infancy, abnormal mitochondria, 3-methylglutaconic aciduria and increased sensitivity to apoptosis.
HTRA2 and ANO3 (Montrer ANO3 Anticorps) mutations are not common causes of essential tremor
HtrA2 under stress conditions induces vimentin (Montrer VIM Anticorps) cleavage in wild-type and SH-SY5Y cells transfected with ABP (Montrer ABP1 Anticorps) with the Alzheimer disease-associated Swedish mutation. Interplay between Omi/HtrA2 and vimentin (Montrer VIM Anticorps) affects mitochondrial distribution in neurons.
The a5 helix of PDZ (Montrer INADL Anticorps) was involved in both, the intra- and intersubunit changes of interactions and thus seems to play an important role in HtrA2 activation.
study examined the association of HTRA2 p.G399S mutation with essential tremor(ET) and Parkinson disease (PD) in Asians and found that HTRA2 p.G399S is rare and does not appear to play a major role in subjects with coexistent ET and PD nor in those with pure ET or PD phenotype
The NG2 (Montrer MCSP Anticorps) proteoglycan (Montrer Vcan Anticorps) protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.
The therapeutic function of HtrA2 in inflammatory diseases is linked with Th17 development and the STAT3 (Montrer STAT3 Anticorps) pathway in splenocytes.
Study show that overexpression of mitochondrial Omi/HtrA2 induces cardiac apoptosis and dysfunction.
Omi/HtrA2-HAX-1 (Montrer HAX1 Anticorps) chain played a significant role in mitochondrial homeostasis.
Mice overexpressing wild-type or G399S mutant HtrA2 have mitochondrial defects resulting in neurodegeneration.
Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 (Montrer E2F1 Anticorps) in differentiated neuroblastoma (Montrer ARHGEF16 Anticorps) cells; E2F1 (Montrer E2F1 Anticorps) is a substrate of Omi.
Protease Omi impairs mitochondrial function by cleaving Hax-1 (Montrer HAX1 Anticorps), which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.
The NG2 (Montrer Vcan Anticorps) proteoglycan (Montrer Vcan Anticorps) protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.
Loss of Omi protease activity results in an abnormal increase of GSK3b, leading to the degradation of PGC (Montrer PGC Anticorps)-1a, which causes an impairment of mitochondrial biogenesis and induces neurodegeneration.
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1 (Montrer MED12 Anticorps).
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase (Montrer MUL1 Anticorps) and increased mitophagy.
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
, HtrA serine peptidase 2
, protease, serine, 25
, serine protease HTRA2, mitochondrial-like
, HtrA-like serine protease
, Omi stress-regulated endoprotease
, high temperature requirement protein A2
, serine protease 25
, serine protease HTRA2, mitochondrial
, serine proteinase OMI
, motor neuron degeneration 2
, omi stress-regulated endoprotease
, serine protease OMI
, protease serine 25