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PRKAA2 Produits

(Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))

Catégories

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

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Catégories PRKAA2 en vedette

PRKAA2 Anticorps

High quality antibodies with extensive validation data.

PRKAA2 Kits ELISA

Reliable ELISA kits for a wide range of species.

PRKAA2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRKAA2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, IF, IHC (p), IP, ICC
Validations
  • (3)
  • (5)
N° du produit ABIN2855639
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF, RNAi, PLA
Validations
  • (6)
N° du produit ABIN519168
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Monkey
Application WB, ELISA, IHC, FACS, ICC, Neut
Validations
  • (7)
N° du produit ABIN5611223
Quantité 0.1 mg
Fiche technique Fiche technique

PRKAA2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969726
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1119512
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Pig
Analytical Method
Validations
N° du produit ABIN1119511
Quantité 96 tests
Fiche technique Fiche technique

PRKAA2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect cells (Sf21)
Validations
  • (2)
N° du produit ABIN5569698
Quantité 5 μg
Fiche technique Fiche technique
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7321284
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124658
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRKAA2

Gao, Yuan, Wang, Lei, Shen, Cui, Zhang, Ding, Lu: "Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2." dans: Redox biology, Vol. 28, pp. 101345, (2020) (PubMed).

Derkach, Zakharova, Zorina, Bakhtyukov, Romanova, Bayunova, Shpakov: "The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect." dans: PLoS ONE, Vol. 14, Issue 3, pp. e0213779, (2019) (PubMed).

Zhang, Zhang, Zhou, Fu, Michal, Ji, Du, Davis, Jiang: "Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice." dans: Scientific reports, Vol. 8, Issue 1, pp. 6462, (2018) (PubMed).

Li, Sharma, Yin, Tan, Xiao: "Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice." dans: Molecular medicine reports, Vol. 16, Issue 1, pp. 680-686, (2017) (PubMed).

Liu, Xiao, Han, Zhang, Lee, Wang, Lee, Zhuang, Chen, Lin, Wang, Liang, Gan: "LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress." dans: Nature cell biology, Vol. 18, Issue 4, pp. 431-42, (2016) (PubMed).

Fu, Zhu, Dodson, Du: "AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration." dans: The Journal of biological chemistry, Vol. 290, Issue 44, pp. 26445-56, (2015) (PubMed).

Jaitovich, Angulo, Lecuona, Dada, Welch, Cheng, Gusarova, Ceco, Liu, Shigemura, Barreiro, Patterson, Nader, Sznajder: "High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1)." dans: The Journal of biological chemistry, Vol. 290, Issue 14, pp. 9183-94, (2015) (PubMed).

Hindupur, Balaji, Saxena, Pandey, Sravan, Heda, Kumar, Mukherjee, Dey, Rangarajan: "Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells." dans: Breast cancer research : BCR, Vol. 16, Issue 4, pp. 420, (2015) (PubMed).

Wang, Zhang, Zhang, Liang, Zhu, Lee, Viollet, Xia, Zhang, Zou: "Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo." dans: Nature medicine, Vol. 18, Issue 6, pp. 902-10, (2012) (PubMed).

Lin, Kiihl, Suhail, Liu, Chou, Kuang, Lu, Khor, Lin, Bader, Irizarry, Boeke: "Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK." dans: Nature, Vol. 482, Issue 7384, pp. 251-5, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2), protein kinase AMP-activated catalytic subunit alpha 2 (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog (prkaa2.S), protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2), 2310008I11Rik, A830082D05, AMPK, Ampk, ampk, AMPK2, ampk2, AMPKa2, Ampka2, AMPKA2, AMPKalpha2, PRKAA, prkaa, prkaa1, PRKAA2

Protein level used designations for PRKAA2

  • 5'-AMP-activated protein kinase catalytic subunit alpha-2
  • 5'-AMP-activated protein kinase, catalytic alpha-2 chain
  • ACACA kinase
  • AMPK subunit alpha-2
  • AMPK-alpha-2 chain
  • HMGCR kinase
  • acetyl-CoA carboxylase kinase
  • hydroxymethylglutaryl-CoA reductase kinase
  • AMP-activated protein kinase
  • AMPK alpha-2 chain
  • AMP-activated protein kinase alpha-2 variant B
  • AMP-activated protein kinase alpha 2
  • protein kinase AMP-activated alpha 2 catalytic subunit
  • SNF1-like protein AMPK
  • 5'-AMP-activated protein kinase alpha-2 catalytic subunit
  • AMPKalpha2
  • ampka2
  • AMP-activated protein kinase alpha 2 catalytic subunit
  • protein kinase, AMP-activated, alpha 2 catalytic subunit
  • AMPK-activated protein kinase alpha-2 subunit
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