BMPR2 Protein (AA 27-151) (His tag)

N° du produit ABIN1096143

Détail du produit

Antigène: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Type de proteíne: Recombinant

Attributs du protein: AA 27-151

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette BMPR2 protéine est marqué à la His tag.

Fonction: Recombinant Human BMP Receptor II/BMPR2/PPH1 (C-6His)

Séquence: SQNQERLCAF KDPYQQDLGI GESRISHENG TILCSKGSTC YGLWEKSKGD INLVKQGCWS HIGDPQECHY EECVVTTTPP SIQNGTYRFC CCSTDLCNVN FTENFPPPDT TPLSPPHSFN RDETIVDHHH HHH

Attributs du produit: Recombinant Human Bone Morphogenetic Protein Receptor Type II/BMPR-II produced by transfected human cells is a secreted protein with sequence (Ser27-Ile151) of Human BMPR2 fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Autre désignation: bmpr-ii (BMPR2 Produits)

Synonymes: BMPR-II Protein, BMPR3 Protein, BMR2 Protein, BRK-3 Protein, PPH1 Protein, T-ALK Protein, 2610024H22Rik Protein, AL117858 Protein, AW546137 Protein, BB189135 Protein, BMP-2 Protein, BMPR-2 Protein, BMPRII Protein, Gm20272 Protein, Bmpr-II Protein, bmprii Protein, bone morphogenetic protein receptor type 2 Protein, bone morphogenetic protein receptor, type II b (serine/threonine kinase) Protein, bone morphogenetic protein receptor, type II (serine/threonine kinase) Protein, BMPR2 Protein, bmpr2b Protein, Bmpr2 Protein

Sub Type: Fusionprotein

Sujet: Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.
Alternative Names: Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-2, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor, BMPR-II, BMPR2, PPH1

Poids moléculaire: 15.05 kDa

UniProt: Q13873

Pathways: Growth Factor Binding