ZBTB17 Protein (AA 1-188) (His tag)

N° du produit ABIN1097149

Détail du produit

Antigène: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Type de proteíne: Recombinant

Attributs du protein: AA 1-188

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ZBTB17 protéine est marqué à la His tag.

Fonction: Recombinant Human ZBTB17/Miz-1 (N-6His)

Séquence: MGSSHHHHHH SSGLVPRGSH MDFPQHSQHV LEQLNQQRQL GLLCDCTFVV DGVHFKAHKA VLAACSEYFK MLFVDQKDVV HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVATFLQ MQDIITACHA LKSLAEPATS PGGNAEALAT EGGDKRAKEE KVATSTLSRL EQAGRSTPIG PSRDLKEERG GQAQSAASGA EQTEKADA

Attributs du produit: Recombinant Human Zinc Finger and BTB Domain-Containing Protein 17/ZBTB17 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ala188) of Human ZBTB17 fused with a His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.25.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Autre désignation: Miz-1/ZBTB17 (ZBTB17 Produits)

Synonymes: MIZ-1 Protein, ZNF151 Protein, ZNF60 Protein, pHZ-67 Protein, AA589413 Protein, Lp-1 Protein, Miz1 Protein, Zfp100 Protein, mZ13 Protein, Miz-1 Protein, zbtb17 Protein, zinc finger and BTB domain containing 17 Protein, zinc finger and BTB domain containing 17 S homeolog Protein, ZBTB17 Protein, Zbtb17 Protein, zbtb17.S Protein

Sub Type: Fusionprotein

Sujet: Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific genes, it has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. ZBTB17 may has growth arrest activity, probably through inhibition of cell cycle progression. ZBTB17 required for early embryonic development during gastrulation. ZBTB17 induces cell arrest at G1, an effect mediated by its activation of the gene coding for P15INK4b. This effect is blocked by Myc, which displaces transcriptional coactivators bound to ZBTB17. Although the downregulation of ZBTB17 may contribute to Myc-induced cell transformation, the de-activation of ZBTB17 is absolutely essential for Myc-induced apoptosis.
Alternative Names: Zinc Finger and BTB Domain-Containing Protein 17, Myc-Interacting Zinc Finger Protein 1, Miz-1, Zinc Finger Protein 151, Zinc Finger Protein 60, ZBTB17, MIZ1, ZNF151, ZNF60

Poids moléculaire: 22.33 kDa

UniProt: Q13105

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, ER-Nucleus Signaling