SPINK1 Protein (AA 24-79) (His tag)

N° du produit ABIN1097574

Détail du produit

Antigène: SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))

Type de proteíne: Recombinant

Attributs du protein: AA 24-79

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette SPINK1 protéine est marqué à la His tag.

Fonction: Recombinant Human Serpin Kazal-1 (C-6His)

Séquence: DSLGREAKCY NELNGCTKIY DPVCGTDGNT YPNECVLCFE NRKRQTSILI QKSGPCVDHH HHHH

Attributs du produit: Recombinant Human Serine Protease Inhibitor Kazal-Type 1/SPINK1 produced by transfected human cells is a secreted protein with sequence (Asp24-Cys79) of Human SPINK1 fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 2 mM CaCl2, 1 mM DTT, 0.05 % Brij35, 10 % Glycerol, pH 6.0.

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))

Autre désignation: spink1 (SPINK1 Produits)

Synonymes: PCTT Protein, PSTI Protein, Spink3 Protein, TATI Protein, TCP Protein, Psti Protein, SPINK1 Protein, p12 Protein, serine peptidase inhibitor, Kazal type 1 Protein, SPINK1 Protein, Spink1 Protein

Sub Type: Fusionprotein

Sujet: Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE as well as cancerous prostate cells. The research result indicated that the potential of SPINK1 as an extracellular therapeutic target in prostate cancer. In contrast, knockdown of SPINK1 in 22RV1 cells inhibited cell proliferation, cell invasion, and tumor growth in xenograft assays.
Alternative Names: Pancreatic Secretory Trypsin Inhibitor, Serine Protease Inhibitor Kazal-Type 1, Tumor-Associated Trypsin Inhibitor, TATI, SPINK1, PSTI

Poids moléculaire: 7.28 kDa

UniProt: P00995