CLIC2 Protein (AA 1-247) (His tag)

N° du produit ABIN1097817

Détail du produit

Antigène: CLIC2 (Chloride Intracellular Channel 2 (CLIC2))

Type de proteíne: Recombinant

Attributs du protein: AA 1-247

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CLIC2 protéine est marqué à la His tag.

Fonction: Recombinant Human Chloride Intracellular Channel Protein 2/CLIC2 (N-6His)

Séquence: MGSSHHHHHH SSGLVPRGSH MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA NVAKQKS

Attributs du produit: Recombinant Human Chloride Intracellular Channel Protein 2/CLIC2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ser247) of Human CLIC2 fused with a His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 1 mM DTT, 20 % Glycerol, pH 8.0.

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: CLIC2 (Chloride Intracellular Channel 2 (CLIC2))

Autre désignation: Chloride Intracellular Channel Protein 2/CLIC2 (CLIC2 Produits)

Synonymes: zgc:92762 Protein, CLIC2 Protein, CLIC2b Protein, MRXS32 Protein, XAP121 Protein, chloride intracellular channel 2 Protein, clic2 Protein, CLIC2 Protein, Clic2 Protein

Sub Type: Fusionprotein

Sujet: Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells, it regulates cellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
Alternative Names: Chloride Intracellular Channel Protein 2, XAP121, CLIC2

Poids moléculaire: 30.5 kDa

UniProt: O15247

Pathways: Negative Regulation of Transporter Activity