UMPS Protein (His tag)

N° du produit ABIN1098695

Détail du produit

Antigène: UMPS (Uridine Monophosphate Synthetase (UMPS))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette UMPS protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Pureté: > 90 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: Uridine 5'-monophosphate synthase, OPRT

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 2 M Urea, 20% glycerol

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: UMPS (Uridine Monophosphate Synthetase (UMPS))

Autre désignation: UMPS (UMPS Produits)

Synonymes: zgc:55702 Protein, zgc:55723 Protein, UMPS Protein, OPRT Protein, 1700095D23Rik Protein, AA408257 Protein, AL033308 Protein, BB164745 Protein, Orotidine 5'-phosphate decarboxylase Protein, uridine monophosphate synthetase Protein, uridine monophosphate synthetase L homeolog Protein, uridine 5'-monophosphate synthase Protein, umps-1 Protein, umps Protein, umps.L Protein, UMPS Protein, LOC100556619 Protein, Umps Protein

Sujet: Uridine 5'-monophosphate synthase, also known as UMPS, is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. Unlike prokaryotes, UMPS in eukaryotes combines the orotate phosphoribosyltransferase and the orotidine-5’-monophosphate (OMP) decarboxylase activities into a single protein. The union of these two enzymes is thought to stabilize the catalytic centers due to the low molar concentration of the protein in mammalian cells. Defects in this gene are the cause of hereditary orotic aciduria. Recombinant human UMPS protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 54.3 kDa (500aa)

NCBI Accession: NP_000364

Pathways: Ribonucleoside Biosynthetic Process