HMGB1 Protein (BoxB Domain)

N° du produit ABIN1176819

Détail du produit

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: BoxB Domain

Origine: Humain, Souris

Source: Escherichia coli (E. coli)

Application: Activation (Act), Cellular Assay (CA)

Séquence: MARIDPNAPK RPPSAFFLFC SEYRPKIKGE HPGLSIGDVA KKLGEMWNNT AADDKQPYEK KAAKLKEKYE KDIAAYRAKG KPDAAKKGVV

Attributs du produit: BoxB recapitulates the cytokine activity of full length HMGB1 and efficiently activates macrophages to release tumor necrosis factor (TNF- ) and other proinflammatory cytokines (Li et al 2004). This product contains four amino acids (MARI) that have been added at the N terminus for the purpose of expression in bacteria. It contains only trace amounts of LPS (<0.4 ng/mg protein).

Purification: Purified

Pureté: > 95 %

niveau d'endotoxine: The purified protein is free from LPS (Cambrex Limulus Amoebocyte Assay QCL-1000, <0.4 ng LPS per mg protein).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM HEPES buffer pH 7.9, 500 mM NaCl, 0.5 mM DTT.

Stock: 4 °C/-20 °C

Stockage commentaire: The protein once resuspended can be stored frozen (-20°C).

Détail du antigène

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Autre désignation: High-mobility group protein B1 (HMGB1) (HMGB1 Produits)

Synonymes: HMG1 Protein, HMG3 Protein, SBP-1 Protein, DEF Protein, HMG-1 Protein, Hmg1 Protein, amphoterin Protein, p30 Protein, hmgb1 Protein, ik:tdsubc_1a5 Protein, wu:fb23c02 Protein, xx:tdsubc_1a5 Protein, zgc:56110 Protein, zgc:77104 Protein, hmg-1 Protein, hmg3 Protein, sbp-1 Protein, hmg1 Protein, HMGB1 Protein, Ac2-008 Protein, high mobility group box 1 Protein, high-mobility group box 1 Protein, high mobility group box 1a Protein, high mobility group box 1 L homeolog Protein, high mobility group protein B1 Protein, HMGB1 Protein, Hmgb1 Protein, hmgb1 Protein, hmgb1a Protein, hmgb1.L Protein, LOC100359149 Protein

Sujet: BoxB is one of the DNA binding domains of HMGB1 protein. It consists of 90 amino acids and has a calculated molecular mass of approximately 10 kDa. The sequence of BoxB is totally identical in human and mouse.

Poids moléculaire: approximately 10 kDa

Pathways: Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome