FIL1h Protein (AA 8-160) (His tag)

N° du produit ABIN1344001

Détail du produit

Antigène: FIL1h (Interleukin 1 eta (FIL1h))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 8-160

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette FIL1h protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Mouse IL-36alpha (aa Arg8-His160) is untagged.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Induces secretion of IL-6 in BMDCs at a concentration of 100ng - 1μg/ml.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: FIL1h (Interleukin 1 eta (FIL1h))

Autre désignation: IL-36 beta (FIL1h Produits)

Synonymes: 2310043N20Rik Protein, Il36b Protein, FIL1 Protein, FIL1-(ETA) Protein, FIL1H Protein, FILI-(ETA) Protein, IL-1F8 Protein, IL-1H2 Protein, IL1-ETA Protein, IL1F8 Protein, IL1H2 Protein, Il1f8 Protein, interleukin 1 family, member 8 Protein, interleukin 36 beta Protein, interleukin 36, beta Protein, Il1f8 Protein, IL36B Protein, Il36b Protein

Sujet: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36alpha in the pathogenesis of intestinal inflammation has been reported.

Poids moléculaire: ~17kDa

UniProt: Q9JLA2