NUCB2 Protein (AA 25-420) (His tag)

N° du produit ABIN1344143

Détail du produit

Antigène: NUCB2 (Nucleobindin 2 (NUCB2))

Type de proteíne: Recombinant

Attributs du protein: AA 25-420

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NUCB2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Mouse nucleobindin-2 (aa 25-420) is fused at the C-terminus to a His-tag.

Pureté: >90 % (SDS-PAGE)

Stérilité: 0.2 μm filtered

niveau d'endotoxine: <1EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.2.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: NUCB2 (Nucleobindin 2 (NUCB2))

Autre désignation: NUCB2 (NUCB2 Produits)

Synonymes: nefa Protein, MGC97715 Protein, NUCB2 Protein, nucleobindin-2 Protein, NEFA Protein, AI607786 Protein, Calnuc Protein, Nefa Protein, Nesfatin-1 Protein, p54 Protein, nucleobindin 2 Protein, nucleobindin 2 L homeolog Protein, nucb2 Protein, NUCB2 Protein, Nucb2 Protein, nucb2.L Protein

Sujet: Nucleobindin-2 (NUCB2, Prepronesfatin) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucleobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. NUCB2 can be cleaved into three polypeptides: nesfatin-1, nesfatin-2, and nesfatin-3. Anorexigenic effects have been described for nesfatin-1 that plays an important role in hypothalamic pathways regulating food intake and energy homeostasis and acting in a leptin-independent manner. Nesfatin-1 may also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. Nucleobindin-2 is therefore reported to reduce food intake after administration, mostly refering to the cleaved peptide nesfatin-1. Excess nucleobindin-2/nesfatin-1 in the brain leads to a loss of appetite, lack of the protein in the brain leads to an increase of appetite.

Poids moléculaire: ~55kDa (SDS-PAGE)

UniProt: P81117