TNFSF18 Protein (AA 45-173, Extracellular Domain, Soluble) (DYKDDDDK Tag)

N° du produit ABIN1344404

Détail du produit

Antigène: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: Soluble, Extracellular Domain, AA 45-173

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette TNFSF18 protéine est marqué à la DYKDDDDK Tag.

Application: SDS-PAGE (SDS)

Specificité: Binds to mouse GITR.

Réactivité croisée: Souris

Attributs du produit: The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.

Pureté: >90 % (SDS-PAGE)

Stérilité: 0.2 μm filtered

niveau d'endotoxine: <0.1EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Induces GITR-mediated NF-kappaB activation in HEK 293 cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in 10 mM glycine, pH 10.0.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 3 months

Détail du antigène

Antigène: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Autre désignation: GITRL (TNFSF18 Produits)

Synonymes: Gitrl Protein, AITRL Protein, GITRL Protein, TL6 Protein, hGITRL Protein, TNLG2A Protein, tumor necrosis factor (ligand) superfamily, member 18 Protein, TNF superfamily member 18 Protein, Tnfsf18 Protein, TNFSF18 Protein

Sujet: GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Poids moléculaire: ~22kDa (SDS-PAGE)

UniProt: Q7TS55