HMOX1 Protein (partial) (His tag)

N° du produit ABIN1686745

Détail du produit

Antigène: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Type de proteíne: Recombinant

Attributs du protein: partial

Origine: Rat

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HMOX1 protéine est marqué à la His tag.

Application: Western Blotting (WB), SDS-PAGE (SDS)

Séquence: MERPQLDSMS QDLSEALKEA TKEVHIRAEN SEFMRNFQKG QVSREGFKLV MASLYHIYTA LEEEIERNKQ NPVYAPLYFP EELHRRAALE QDMAFWYGPH WQEAIPYTPA TQHYVKRLHE VGGTHPELLV AHAYTRYLGD LSGGQVLKKI AQKAMALPSS GEGLAFFTFP SIDNPTKFKQ LYRARMNTLE MTPEVKHRVT EEAKTAFLLN IELFEELQAL LTEEHKDQSP SQTEFLRQRP ASLVQDTTSA ETPRGKSQIS T

Specificité: ~32 kDa

Purification: Affinity Purified

Pureté: >90%

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

This product has been certified >90% pure using SDSPAGE analysis.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: 50 mM Tris/HCl pH 7.5, 5 mM Bme, 0.15NaCl, 10 % glycerol

Stock: -20 °C

Détail du antigène

Antigène: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Autre désignation: HO-1 (HMOX1 Produits)

Synonymes: HMOX1 Protein, ARABIDOPSIS THALIANA HEME OXYGENASE 1 Protein, ATHO1 Protein, F18A8.4 Protein, F18A8_4 Protein, GENOMES UNCOUPLED 2 Protein, GUN2 Protein, HEME OXYGENASE Protein, HEME OXYGENASE 1 Protein, HEME OXYGENASE 6 Protein, HO1 Protein, HY1 Protein, HY6 Protein, PLASTID HEME OXYGENASE Protein, REVERSAL OF THE DET PHENOTYPE 4 Protein, HO-1 Protein, wu:fc27c04 Protein, zgc:65984 Protein, D8Wsu38e Protein, Hemox Protein, Hmox Protein, Hsp32 Protein, HEOXG Protein, Heox Protein, Ho-1 Protein, Ho1 Protein, hsp32 Protein, MGC132176 Protein, Hmox1 Protein, HMOX1D Protein, HSP32 Protein, bK286B10 Protein, heme oxygenase 1 Protein, Plant heme oxygenase (decyclizing) family protein Protein, Heme oxygenase Protein, heme oxygenase Protein, heme oxygenase 1, chloroplastic Protein, heme oxygenase 1a Protein, heme oxygenase 1 L homeolog Protein, HMOX1 Protein, TED4 Protein, ho1 Protein, P9301_RS17555 Protein, A9601_RS17590 Protein, MAE_RS06565 Protein, HO1 Protein, hmox1a Protein, CPE0214 Protein, Cyan7425_2962 Protein, Hmox1 Protein, hmox1.L Protein, AM1_C0205 Protein, CC1G_11686 Protein, CpipJ_CPIJ007246 Protein

Sujet: Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator, biliverdin and bilirubin are potent antioxidants, and the free iron increases oxidative stress and regulates the expression of many mRNAs (2).There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3, however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).

Poids moléculaire: Approx. 32 kDa

ID gène: 24451

NCBI Accession: NP_036712

UniProt: P06762

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome