TNFRSF18 Protein (AA 22-153) (Fc Tag,His tag)

N° du produit ABIN1691778

Détail du produit

Antigène: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Type de proteíne: Recombinant

Attributs du protein: AA 22-153

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette TNFRSF18 protéine est marqué à la Fc Tag,His tag.

Fonction: Recombinant Mouse GITR/TNFRSF18/CD357 (C-Fc-6His)

Séquence: SVVEEPGCGP GKVQNGSGNN TRCCSLYAPG KEDCPKERCI CVTPEYHCGD PQCKICKHYP CQPGQRVESQ GDIVFGFRCV ACAMGTFSAG RDGHCRLWTN CSQFGFLTMF PGNKTHNAVC IPEPLPTEQY GHVDDIEGRM DEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH

Attributs du produit:

Recombinant Mouse GITR/TNFRSF18/CD357 (C-Fc-6His)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Autre désignation: GITR/TNFRSF18 (TNFRSF18 Produits)

Synonymes: GITR Protein, TNFRSF18 Protein, AITR Protein, Gitr Protein, CD357 Protein, GITR-D Protein, TNF receptor superfamily member 18 Protein, tumor necrosis factor receptor superfamily, member 18 Protein, TNFRSF18 Protein, Tnfrsf18 Protein

Sujet: Recombinant Mouse Tumor necrosis factor receptor superfamily member 18/GITR/TNFRSF18 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser22-His153) of Mouse TNFRSF18 fused with a FC-6His tag at the C-terminus.
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isoforms. IsoformA, isoformB and isoformC is single-pass type I membrane protein and isoformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-κB activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Poids moléculaire: 42.3 kDa

UniProt: O35714

Pathways: Cancer Immune Checkpoints