TNFSF18 Protein (AA 74-198)

N° du produit ABIN2017653

Détail du produit

Antigène: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 74-198

Origine: Humain

Source: Escherichia coli (E. coli)

Attributs du produit: ED50 < 5 ng/mL, measured by the amount of Interleukin-8 produced by PMBC, corresponding to a specific activity of > 2.0 x 10^5 units/mg.
AA 74-198, expressed with an N-terminal Met.

Pureté: > 95 % by SDS-PAGE analysis.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 50 mM Tris, pH 8.0.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhAITRL remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Autre désignation: Activation-Inducible TNF-Related Ligand (AITRL) (TNFSF18 Produits)

Synonymes: Gitrl Protein, AITRL Protein, GITRL Protein, TL6 Protein, hGITRL Protein, TNLG2A Protein, tumor necrosis factor (ligand) superfamily, member 18 Protein, TNF superfamily member 18 Protein, Tnfsf18 Protein, TNFSF18 Protein

Sujet: Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen-presenting cells. Upon binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) produced in E. coli is a single non-glycosylated polypeptide chain containing 126 amino acids. A fully biologically active molecule, rhAITRL has a molecular mass of 14.3 kDa analyzed by reducing SDS-PAGE.
Synonyms: Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6

Poids moléculaire: 14.3 kDa, observed by reducing SDS-PAGE.

UniProt: Q9UNG2