IL-11 Protein (AA 23-199)
Aperçu rapide pour IL-11 Protein (AA 23-199) (ABIN2018055)
Antigène
Voir toutes IL-11 (IL11) ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Attributs du protein
- AA 23-199
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Attributs du produit
- ED50 < 3 ng/mL, measured in a cell proliferation assay using T11 cells.
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niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Stock
- -80 °C
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Stockage commentaire
- Lyophilized recombinant Murine Interleukin-11 (IL-11) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Murine Interleukin-11 (IL-11) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Date de péremption
- 6 months
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- IL-11 (IL11) (Interleukin 11 (IL11))
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Autre désignation
- Interleukin-11(IL-11)
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Sujet
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Interleukin-11 (IL-11) is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1alpha-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.
Synonyms: IL-11 -
Poids moléculaire
- 21 kDa, observed by reducing SDS-PAGE.
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UniProt
- P47873
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Pathways
- Signalistation JAK/STAT, Negative Regulation of Hormone Secretion
Antigène
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