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IL-11 Protein (AA 23-199)

Cette protéine Recombinant IL-11 est produite dans HEK-293T Cells.
N° du produit ABIN2018055

Aperçu rapide pour IL-11 Protein (AA 23-199) (ABIN2018055)

Antigène

Voir toutes IL-11 (IL11) Protéines
IL-11 (IL11) (Interleukin 11 (IL11))

Type de proteíne

Recombinant

Activité biologique

Active

Origine

  • 19
  • 11
  • 2
  • 2
Souris

Source

  • 19
  • 7
  • 2
  • 2
  • 2
  • 1
  • 1
HEK-293T Cells

Pureté

> 95 % as analyzed by SDS-PAGE and HPLC.
  • Attributs du protein

    AA 23-199

    Attributs du produit

    ED50 < 3 ng/mL, measured in a cell proliferation assay using T11 cells.

    niveau d'endotoxine

    < 0.2 EU/μg, determined by LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Stock

    -80 °C

    Stockage commentaire

    Lyophilized recombinant Murine Interleukin-11 (IL-11) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Murine Interleukin-11 (IL-11) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

    Date de péremption

    6 months
  • Antigène

    IL-11 (IL11) (Interleukin 11 (IL11))

    Autre désignation

    Interleukin-11(IL-11)

    Sujet

    Interleukin-11 (IL-11) is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1alpha-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.
    Synonyms: IL-11

    Poids moléculaire

    21 kDa, observed by reducing SDS-PAGE.

    UniProt

    P47873

    Pathways

    Signalistation JAK/STAT, Negative Regulation of Hormone Secretion
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