IL-11 Protein (AA 22-199) (His tag)

N° du produit ABIN7013692

Détail du produit

Antigène: IL-11 (IL11) (Interleukin 11 (IL11))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 22-199

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL-11 protéine est marqué à la His tag.

Fonction: Human IL-11 Protein, His Tag

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: IL-11 (IL11) (Interleukin 11 (IL11))

Autre désignation: IL-11 (IL11 Produits)

Synonymes: IL11 Protein, AGIF Protein, IL-11 Protein, Il-11 Protein, interleukin 11 Protein, IL11 Protein, Il11 Protein

Sujet: Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.

Poids moléculaire: 21.0 kDa

NCBI Accession: NP_000632

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion