Neuroserpin Protein (AA 17-410)

N° du produit ABIN2018280

Détail du produit

Antigène: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 17-410

Origine: Humain

Source: CHO Cells

Attributs du produit: ED50 < 2 μg/mL, measured by the dose-dependent stimulation of the proliferation of rat C6 cells, corresponding to a specific activity of > 500 units/mg.

Pureté: > 95 % as analyzed by SDS-PAGE and HPLC.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant Human Neuroserpin remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rh_Neuroserpin should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Autre désignation: Neuroserpin (SERPINI1 Produits)

Synonymes: PI12 Protein, neuroserpin Protein, AI837402 Protein, Ns Protein, PI-12 Protein, Spi17 Protein, CG9453 Protein, Dmel\\CG9453 Protein, Serp2 Protein, Sp4 Protein, Spn4 Protein, Spn4A Protein, dSerp2 Protein, sp4 Protein, spn4 Protein, raPIT5a Protein, SERPINI1 Protein, pi12 Protein, serpini1l Protein, si:ch211-167c22.4 Protein, serpin family I member 1 Protein, serine (or cysteine) peptidase inhibitor, clade I, member 1 Protein, Serpin 42Da Protein, serpin peptidase inhibitor, clade I (neuroserpin), member 1 Protein, serpin family I member 1 L homeolog Protein, SERPINI1 Protein, Serpini1 Protein, Spn42Da Protein, serpini1 Protein, serpini1.L Protein

Sujet: Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala. The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB).
Synonyms: Serpin I1, Protease inhibitor 12

Poids moléculaire: 40-45 kDa, observed by non-reducing SDS-PAGE.

UniProt: Q99574

Pathways: Regulation of Hormone Metabolic Process