Neuroserpin Protein (His tag)

N° du produit ABIN7320111

Détail du produit

Antigène: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette Neuroserpin protéine est marqué à la His tag.

Fonction: Recombinant Mouse SerpinI1/Neuroserpin Protein (His Tag)

Séquence: Met 1-Leu 410

Attributs du produit: A DNA sequence encoding the mouse SERPINI1 (O35684) (Met 1-Leu 410) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Autre désignation: SerpinI1/Neuroserpin (SERPINI1 Produits)

Synonymes: PI12 Protein, neuroserpin Protein, AI837402 Protein, Ns Protein, PI-12 Protein, Spi17 Protein, CG9453 Protein, Dmel\\CG9453 Protein, Serp2 Protein, Sp4 Protein, Spn4 Protein, Spn4A Protein, dSerp2 Protein, sp4 Protein, spn4 Protein, raPIT5a Protein, SERPINI1 Protein, pi12 Protein, serpini1l Protein, si:ch211-167c22.4 Protein, serpin family I member 1 Protein, serine (or cysteine) peptidase inhibitor, clade I, member 1 Protein, Serpin 42Da Protein, serpin peptidase inhibitor, clade I (neuroserpin), member 1 Protein, serpin family I member 1 L homeolog Protein, SERPINI1 Protein, Serpini1 Protein, Spn42Da Protein, serpini1 Protein, serpini1.L Protein

Sujet:

Background: Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein which belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. Neuroserpin is predominantly expressed in the brain, and is expressed in the late stages of neurogenesis during the process of synapse formation. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. Neuroserpin may also protect neurons from cell damage by tissue-type plasminogen activator. Defects of neuroserpin are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B).

Synonym: AI837402,Ns,PI-12,PI12,Spi17

Poids moléculaire: 46 kDa

UniProt: O35684

Pathways: Regulation of Hormone Metabolic Process