CD137 Protein (AA 24-186) (Fc Tag)

N° du produit ABIN2180547

Détail du produit

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 24-186

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD137 protéine est marqué à la Fc Tag.

Séquence: AA 24-186

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.3 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Détail du antigène

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Autre désignation: 4-1BB (TNFRSF9 Produits)

Synonymes: TNFRSF9 Protein, zgc:136557 Protein, 4-1BB Protein, CD137 Protein, CDw137 Protein, ILA Protein, A930040I11Rik Protein, AA408498 Protein, AI325004 Protein, Cd137 Protein, Ly63 Protein, tumor necrosis factor receptor superfamily member 9 Protein, TNF receptor superfamily member 9 Protein, tumor necrosis factor receptor superfamily, member 9a Protein, tumor necrosis factor receptor superfamily, member 9 Protein, TNFRSF9 Protein, tnfrsf9a Protein, Tnfrsf9 Protein

Sujet: 4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

Poids moléculaire: 43.4 kDa

NCBI Accession: NP_001552

Pathways: Cancer Immune Checkpoints