CD79b Protein (AA 29-159) (Fc Tag)

N° du produit ABIN2180837

Détail du produit

Antigène: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Type de proteíne: Recombinant

Attributs du protein: AA 29-159

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD79b protéine est marqué à la Fc Tag.

Séquence: AA 29-159

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.8 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >90 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 0.1 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Référence

Ding, Mao, Cao, Wang, Xu, Zhou: "Targeting CD79b for Chimeric Antigen Receptor T-Cell Therapy of B-Cell Lymphomas." dans: Targeted oncology, Vol. 15, Issue 3, pp. 365-375, (2020) (PubMed).

Détail du antigène

Antigène: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Autre désignation: CD79B (CD79B Produits)

Sujet: B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

Poids moléculaire: 41.8 kDa

NCBI Accession: NP_000617

Pathways: BCR Signaling