Coxsackie Adenovirus Receptor Protein (AA 20-237) (His tag)

N° du produit ABIN2180951

Détail du produit

Antigène: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Type de proteíne: Recombinant

Attributs du protein: AA 20-237

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Coxsackie Adenovirus Receptor protéine est marqué à la His tag.

Séquence: AA 20-237

Attributs du produit: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Détail du antigène

Antigène: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Autre désignation: CXADR (CXADR Produits)

Synonymes: CAR Protein, CAR4/6 Protein, HCAR Protein, Car1 Protein, car Protein, cb331 Protein, fb76g12 Protein, wu:fb76g12 Protein, 2610206D03Rik Protein, AU016810 Protein, AW553441 Protein, MCAR Protein, MCVADR Protein, hcar Protein, xCAR Protein, CXADR Protein, CXADR, Ig-like cell adhesion molecule Protein, coxsackie virus and adenovirus receptor Protein, CXADR, Ig-like cell adhesion molecule L homeolog Protein, CXADR Protein, Cxadr Protein, cxadr Protein, cxadr.L Protein

Sujet: Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V- type (D1) and a C2- type (D2) Ig-like domain, a  transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

Poids moléculaire: 24.9 kDa

NCBI Accession: NP_001329

Pathways: Cell-Cell Junction Organization