Fc epsilon RI/FCER1A Protein (AA 26-205) (His tag)
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- Antigène Voir toutes Fc epsilon RI/FCER1A (FCER1A) Protéines
- Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 26-205
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Fc epsilon RI/FCER1A protéine est marqué à la His tag.
- Séquence
- AA 26-205
- Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.9 kDa. The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FCER1A Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Antigène
- Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
- Autre désignation
- FCER1A (FCER1A Produits)
- Synonymes
- FCER1A Protein, FCE1A Protein, FcERI Protein, Iger01 Protein, RATIGER01 Protein, Fce1a Protein, Fcr-5 Protein, fcepsilonri Protein, Fc fragment of IgE receptor Ia Protein, Fc receptor, IgE, high affinity I, alpha polypeptide Protein, FCER1A Protein, Fcer1a Protein
- Sujet
- High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
- Poids moléculaire
- 22.9 kDa
- Pathways
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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