TGFBR2 Protein (AA 23-159) (Fc Tag)

N° du produit ABIN2181811

Détail du produit

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Type de proteíne: Recombinant

Attributs du protein: AA 23-159

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette TGFBR2 protéine est marqué à la Fc Tag.

Séquence: AA 23-159

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Référence

Zhang, Wang, Xue, Lai, Ji, Jin, Chen: "Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling." dans: American journal of translational research, Vol. 9, Issue 1, pp. 115-125, (2017) (PubMed).

Détail du antigène

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Autre désignation: TGFBR2 (TGFBR2 Produits)

Synonymes: AAT3 Protein, FAA3 Protein, LDS1B Protein, LDS2B Protein, MFS2 Protein, RIIC Protein, TAAD2 Protein, TGFR-2 Protein, TGFbeta-RII Protein, 1110020H15Rik Protein, AU042018 Protein, DNIIR Protein, RIIDN Protein, TBR-II Protein, TbetaR-II Protein, TbetaRII Protein, TGFBR2 Protein, TBETA-RII Protein, TGFBRII Protein, TGF-beta 2 Protein, Tgfbr2T Protein, cb537 Protein, tgfbr2 Protein, wu:fj05c10 Protein, zgc:110498 Protein, transforming growth factor beta receptor 2 Protein, transforming growth factor, beta receptor II Protein, transforming growth factor, beta receptor 2 Protein, transforming growth factor beta receptor 2b Protein, TGFBR2 Protein, Tgfbr2 Protein, tgfbr2b Protein

Sujet: TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

Poids moléculaire: 42.1 kDa

NCBI Accession: NP_003233