ATG5 Protein (AA 1-275) (His tag)

N° du produit ABIN2468251

Détail du produit

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Type de proteíne: Recombinant

Attributs du protein: AA 1-275

Origine: Humain, Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ATG5 protéine est marqué à la His tag.

Application: ELISA, Western Blotting (WB), Mass Spectrometry (MS), Neutralization (Neut)

Pureté: ~95 %

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1X PBS containing 10 % glycerol

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Autre désignation: ATG5 (ATG5 Produits)

Synonymes: APG5 Protein, APG5-LIKE Protein, APG5L Protein, ASP Protein, hAPG5 Protein, ATG5 Protein, CG1643 Protein, DmAtg5 Protein, Dmel\\CG1643 Protein, atg5 Protein, 2010107M05Rik Protein, 3110067M24Rik Protein, AW319544 Protein, Apg5l Protein, Atg5l Protein, C88337 Protein, Paddy Protein, apg5l Protein, zgc:100934 Protein, ATATG5 Protein, AUTOPHAGY 5 Protein, MKP11.20 Protein, MKP11_20 Protein, autophagy related 5 Protein, Autophagy-related 5 Protein, ATG5 autophagy related 5 homolog (S. cerevisiae) Protein, autophagy related 5 L homeolog Protein, similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 Protein, autophagy protein Apg5 family Protein, ATG5 Protein, Atg5 Protein, atg5 Protein, atg5.L Protein, APG5 Protein

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). ATG5, another member of the autophagy protein family, forms a conjugate with ATG12 , this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy (4). This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells (5).

Poids moléculaire: 34 kDa (Calculated)

ID gène: 9474

OMIM: 10285391

UniProt: A9UGY9

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy