Endonuclease G Protein (ENDOG) (AA 51-140) (His tag,Strep II tag)

N° du produit ABIN2468369

Détail du produit

Antigène: Endonuclease G (ENDOG)

Type de proteíne: Recombinant

Attributs du protein: AA 51-140

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Endonuclease G protéine est marqué à la His tag,Strep II tag.

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS)

Pureté: ~95 %

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1X PBS containing 0.1 % SDS and 0.02 % NaN

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: Endonuclease G (ENDOG)

Autre désignation: EndoG (ENDOG Produits)

Synonymes: CG8862 Protein, Dmel\\CG8862 Protein, Tb08.10J17.140 Protein, Tb08.10J17.90 Protein, TBC1D13 Protein, endog Protein, ENDOG Protein, wu:fb79c08 Protein, zgc:110020 Protein, Endonuclease G Protein, endonuclease G Protein, putative endonuclease G Protein, endonuclease G, mitochondrial Protein, endonuclease G L homeolog Protein, EndoG Protein, Tc00.1047053506867.10 Protein, Tb927.8.4040 Protein, Tb927.8.4090 Protein, LBRM_10_0750 Protein, LMJF_10_0610 Protein, NAEGRDRAFT_78507 Protein, ENDOG Protein, endog Protein, eNDOG Protein, LOC100529218 Protein, Endog Protein, endog.L Protein

Sujet: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribo-nuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1-3). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndoG also cleaves DNA in vitro (4).

Poids moléculaire: 15 kDa (Calculated)

ID gène: 2021

OMIM: 24638471

UniProt: Q14249

Pathways: Apoptose