VTCN1 Protein (His tag)

N° du produit ABIN2567029

Détail du produit

Antigène: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette VTCN1 protéine est marqué à la His tag.

Application: Western Blotting (WB)

Attributs du produit:

Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes. The ED50 for this effect is typically 0. 75 - 3 μg/mL.

Pureté: >90 % as determined by SDS-PAGE.

Information d'application

Indications d'application: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -80 °C,-20 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Autre désignation: VTCN1 (VTCN1 Produits)

Synonymes: B7h4 Protein, B7s1 Protein, B7x Protein, BC032925 Protein, B7-H4 Protein, B7H4 Protein, B7S1 Protein, B7X Protein, B7h.5 Protein, PRO1291 Protein, VCTN1 Protein, RGD1311204 Protein, V set domain containing T cell activation inhibitor 1 L homeolog Protein, V-set domain containing T cell activation inhibitor 1 Protein, V-set domain containing T-cell activation inhibitor 1 Protein, V set domain containing T cell activation inhibitor 1 Protein, vtcn1.L Protein, VTCN1 Protein, vtcn1 Protein, Vtcn1 Protein

Sujet: V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Poids moléculaire: 26.1 kDa

ID gène: 79679

NCBI Accession: NP_078902

UniProt: Q7Z7D3