ERCC5 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2712283

Détail du produit

Antigène: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ERCC5 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human ERCC5 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Autre désignation: Ercc5 (ERCC5 Produits)

Synonymes: COFS3 Protein, ERCM2 Protein, UVDR Protein, XPG Protein, XPGC Protein, cofs3 Protein, ercm2 Protein, uvdr Protein, xpg Protein, xpgc Protein, Xpg Protein, ERCC excision repair 5, endonuclease Protein, excision repair cross-complementation group 5 L homeolog Protein, excision repair cross-complementing rodent repair deficiency, complementation group 5 Protein, ERCC5 Protein, ercc5.L Protein, Ercc5 Protein

Sujet: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Poids moléculaire: 133.1 kDa

NCBI Accession: NP_000114

Pathways: Réparation de l'ADN