CTNNB1 Protein (His tag)

N° du produit ABIN2713223

Détail du produit

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Type de proteíne: Recombinant

Origine: Humain

Source: Insect cells (Sf9)

Purification/Conjugué: Cette CTNNB1 protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Catenin beta-1 (full length, N-term His tag) protein expressed in sf9 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Autre désignation: Catenin beta-1 (CTNNB1 Produits)

Synonymes: Jup Protein, LOC100217813 Protein, CTNNB1 Protein, CTNNB Protein, Bfc Protein, Catnb Protein, Mesc Protein, ctnnb Protein, id:ibd2058 Protein, wu:fb73e10 Protein, wu:fi81c06 Protein, wu:fk25h01 Protein, ctnnb1 Protein, CHBCAT Protein, MRD19 Protein, armadillo Protein, beta-catenin Protein, catenin beta 1 Protein, catenin (cadherin associated protein), beta 1 Protein, catenin (cadherin-associated protein), beta 1 Protein, catenin beta 1 S homeolog Protein, catenin beta 1 L homeolog Protein, CTNNB1 Protein, Ctnnb1 Protein, ctnnb1 Protein, ctnnb1.S Protein, ctnnb1.L Protein

Sujet: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 85 kDa

NCBI Accession: NP_001895

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2