C11orf73 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2715388

Détail du produit

Antigène: C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette C11orf73 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human C11orf73 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))

Autre désignation: c11orf73 (C11orf73 Produits)

Synonymes: C11orf73 Protein, HSPC179 Protein, Hikeshi Protein, L7RN6 Protein, OPI10 Protein, Hikeshi, heat shock protein nuclear import factor Protein, Hikeshi, heat shock protein nuclear import factor L homeolog Protein, HIKESHI Protein, hikeshi.L Protein, hikeshi Protein, Hikeshi Protein

Sujet: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.

Poids moléculaire: 21.4 kDa

NCBI Accession: NP_057485

Pathways: Protein targeting to Nucleus