ERCC8 Protein (His tag)

N° du produit ABIN2720444

Détail du produit

Antigène: ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ERCC8 protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human ERCC8 (full length, N-term HIS tag, transcript variant 3) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))

Autre désignation: Ercc8 (ERCC8 Produits)

Synonymes: zgc:103550 Protein, CKN1 Protein, CSA Protein, UVSS2 Protein, Ckn1 Protein, 2410022P04Rik Protein, 2810431L23Rik Protein, 4631412O06Rik Protein, B130065P18Rik Protein, Csa Protein, excision repair cross-complementation group 8 Protein, ERCC excision repair 8, CSA ubiquitin ligase complex subunit Protein, excision repaiross-complementing rodent repair deficiency, complementation group 8 Protein, ercc8 Protein, ERCC8 Protein, Ercc8 Protein

Sujet: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 23.2 kDa

NCBI Accession: NP_001007235

Pathways: Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus