GDF3 Protéine
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- Antigène Voir toutes GDF3 Protéines
- GDF3 (Growth Differentiation Factor 3 (GDF3))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Application
- Functional Studies (Func), Antibody Production (AbP), Protein Interaction (PI), Standard (STD)
- Specificité
- Optimal preservation of protein structure, post-translational modifications and functions.
- Attributs du produit
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- Recombinant human GDF3 protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
- Pureté
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- niveau d'endotoxine
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
- Biological Activity Comment
- Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. ED50 for this effect is 100-150 ng/ml.
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- Discover our top product GDF3 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays - Restrictions
- For Research Use only
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- Buffer
- Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
- Conseil sur la manipulation
- Resuspend the protein in the desired concentration in proper buffer
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- GDF3 (Growth Differentiation Factor 3 (GDF3))
- Autre désignation
- Gdf3 (GDF3 Produits)
- Synonymes
- KFS3 Protein, MCOP7 Protein, MCOPCB6 Protein, C78318 Protein, Gdf-3 Protein, Vgr-2 Protein, Vgr2 Protein, ecat9 Protein, RGD1564178 Protein, CVG1 Protein, der Protein, derriere Protein, gdf3-a Protein, vgr-2 Protein, vgr2 Protein, growth differentiation factor 3 Protein, growth differentiation factor 3 S homeolog Protein, GDF3 Protein, Gdf3 Protein, gdf3.S Protein
- Sujet
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients.
- Poids moléculaire
- 26 kDa
- NCBI Accession
- NP_065685
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