GCH1 Protein (His tag)

N° du produit ABIN2722329

Détail du produit

Antigène: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GCH1 protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human GTP cyclohydrolase 1 (GCH1) (full length, N-term HIS tag, transcript variant 2) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Abstract: GCH1 Produits

Synonymes: DYT14 Protein, DYT5 Protein, DYT5a Protein, GCH Protein, GTP-CH-1 Protein, GTPCH1 Protein, HPABH4B Protein, GTP-CH Protein, GTPCH Protein, Gch Protein, MGC89622 Protein, gch1a Protein, wu:fc16b10 Protein, zgc:195269 Protein, GTP cyclohydrolase 1 Protein, GTP cyclohydrolase 1-like Protein, GCH1 Protein, Gch1 Protein, gch1 Protein, Weevi_1190 Protein, Halhy_0838 Protein, Sinme_1220 Protein, Sphch_1077 Protein, LOC100136794 Protein

Sujet: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described however, not all variants give rise to a functional enzyme.

Poids moléculaire: 27.7 kDa

NCBI Accession: NP_001019195