NLRP2 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2726786

Détail du produit

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NLRP2 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human NALP2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Autre désignation: Nalp2 (NLRP2 Produits)

Synonymes: CLR19.9 Protein, NALP2 Protein, NBS1 Protein, PAN1 Protein, PYPAF2 Protein, NLRP2 Protein, E330007A02Rik Protein, Nalp2 Protein, NLR family pyrin domain containing 2 Protein, NACHT, LRR and PYD domains-containing protein 2 Protein, NLR family pyrin domain containing 7 Protein, NLR family, pyrin domain containing 2 Protein, NLRP2 Protein, LOC100301026 Protein, LOC100387349 Protein, NLRP7 Protein, Nlrp2 Protein

Sujet: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 120.3 kDa

NCBI Accession: NP_060322

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome