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Uromodulin Protein (UMOD) (Transcript Variant 1) (Myc-DYKDDDDK Tag)

UMOD Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
N° du produit ABIN2735074
  • Antigène Voir toutes Uromodulin (UMOD) Protéines
    Uromodulin (UMOD)
    Type de proteíne
    Recombinant
    Attributs du protein
    Transcript Variant 1
    Origine
    • 7
    • 3
    • 3
    • 3
    • 1
    • 1
    Humain
    Source
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette Uromodulin protéine est marqué à la Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Attributs du produit
    • Recombinant human Uromodulin (UMOD) (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Pureté
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product UMOD Protéine
  • Indications d'application
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Commentaires

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Stock
    -80 °C
    Stockage commentaire
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Antigène
    Uromodulin (UMOD)
    Abstract
    UMOD Produits
    Synonymes
    ADMCKD2 Protein, FJHN Protein, HNFJ Protein, HNFJ1 Protein, MCKD2 Protein, THGP Protein, THP Protein, urehr4 Protein, uromodulin Protein, UMOD Protein, Umod Protein
    Sujet
    The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
    Poids moléculaire
    67.1 kDa
    NCBI Accession
    NP_003352
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