USP20 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2735100

Détail du produit

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette USP20 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human USP20 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Autre désignation: Usp20 (USP20 Produits)

Synonymes: USP20 Protein, vdu2 Protein, lsfr3a Protein, LSFR3A Protein, VDU2 Protein, hVDU2 Protein, 1700055M05Rik Protein, AI467231 Protein, Vdu2 Protein, im:7151955 Protein, zgc:63661 Protein, universal stress protein Protein, ubiquitin specific peptidase 20 Protein, ubiquitin specific peptidase 20 L homeolog Protein, RR_RS15875 Protein, USP20 Protein, usp20 Protein, Usp20 Protein, usp20.L Protein

Sujet: This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.

Poids moléculaire: 101.7 kDa

NCBI Accession: NP_006667

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling