EDAR Protein (AA 27-183, Extracellular Domain) (Fc Tag)

N° du produit ABIN2745656

Détail du produit

Antigène: EDAR (Ectodysplasin A Receptor (EDAR))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: Extracellular Domain, AA 27-183

Origine: Humain, Souris

Source: CHO Cells

Purification/Conjugué: Cette EDAR protéine est marqué à la Fc Tag.

Application: SDS-PAGE (SDS)

Specificité: Binds to human and mouse EDA-A1.

Réactivité croisée: Humain, Souris

Attributs du produit: The extracellular domain of human EDAR (aa 27-183) is fused at the C-terminus to the Fc portion of human IgG1.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Inhibits EDA-A1 activity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 50 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: EDAR (Ectodysplasin A Receptor (EDAR))

Autre désignation: EDAR (EDAR Produits)

Synonymes: rs3 Protein, edar Protein, EDAR Protein, MGC88893 Protein, DL Protein, ECTD10A Protein, ECTD10B Protein, ED1R Protein, ED3 Protein, ED5 Protein, EDA-A1R Protein, EDA1R Protein, EDA3 Protein, HRM1 Protein, dl Protein, RGD1561714 Protein, ectodysplasin A receptor Protein, ectodysplasin-A receptor Protein, edar Protein, EDAR Protein, Edar Protein

Sujet: The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.

Poids moléculaire: ~50kDa (SDS-PAGE)

UniProt: Q9UNE0

Pathways: Tube Formation, Ubiquitin Proteasome Pathway