FZD5 Protein (AA 27-180) (Fc Tag)

N° du produit ABIN2745685

Détail du produit

Antigène: FZD5 (Frizzled Family Receptor 5 (FZD5))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 27-180

Origine: Humain, Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette FZD5 protéine est marqué à la Fc Tag.

Application: SDS-PAGE (SDS)

Specificité: Binds to human and mouse Wnt3a.

Réactivité croisée: Humain, Souris

Attributs du produit: The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Inhibits Wnt3a activation in a stoechiometric manner.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 50 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: FZD5 (Frizzled Family Receptor 5 (FZD5))

Autre désignation: Frizzled-5 (FZD5 Produits)

Synonymes: C2orf31 Protein, HFZ5 Protein, 5330434N09Rik Protein, AI427138 Protein, Fz-5 Protein, Fz5 Protein, mFz5 Protein, Xfz5 Protein, frizzled5 Protein, frizzled5a Protein, fz5 Protein, fzd5-A Protein, fz2 Protein, fz8c Protein, fzd8c Protein, zg02 Protein, frizzled class receptor 5 Protein, frizzled class receptor 5 S homeolog Protein, FZD5 Protein, Fzd5 Protein, fzd5.S Protein, fzd5 Protein

Sujet: Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.

Poids moléculaire: ~50kDa (SDS-PAGE)

UniProt: Q13467

Pathways: Signalisation WNT