PDCD1LG2
(Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
Type de proteíne
Recombinant
Activité biologique
Active
Attributs du protein
AA 20-219
Origine
Humain
Source
HEK-293 Cells
Purification/Conjugué
Cette PDCD1LG2 protéine est marqué à la Fc Tag.
Séquence
AA 20-219
Attributs du produit
This protein carreis a mouse IgG1 Fc tag at the C-terminus, and has a calculated MW of 48.9 kDa. The predicted N-terminus is Leu 20. The reducing (R) protein migrates as 60-70 kDa in SDS-PAGE due to glycosylation.
PDCD1LG2
Origine: Cynomolgus
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Restrictions
For Research Use only
Format
Lyophilized
Buffer
Tris with Glycine, Arginine and NaCl, pH 7.5
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Tocheva, Lerrer, Mor: "In Vitro Assays to Study PD-1 Biology in Human T Cells." dans: Current protocols in immunology, Vol. 130, Issue 1, pp. e103, (2020) (PubMed).
Antigène
PDCD1LG2
(Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.